Barnidipine hydrochloride (YM-09730-5 hydrochloride) is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery

[3H]-Initrendipine:0.21 nmol/l (Ki)

Barnidipine通过降低外周血管阻力来展现其降血压活性。在每日口服1和3 mg/kg的剂量下，能够降低自发性高血压大鼠的血压[1]。含有Barnidipine的制剂已被用作治疗高血压。在有阻塞性睡眠窒息症并且是非dipper型高血压的患者中，Barnidipine能够降低夜间平均收缩压和舒张压[2]。

Forty-one patients (mean age 69 ± 17 years, 18 females) with previously diagnosed OSA (by reduced channel home-based polysomnography) who were not being treated with continuous positive airway pressure (CPAP) because of contraindications or because of patient intolerance or rejection were evaluated. Non-dipper status was defined as the presence of a nighttime fall in systolic blood pressure (BP) which was < 10% that of daytime systolic BP as observed in a previous ambulatory blood pressure (ABP) monitoring. OSA was defined according to the presence of 5 or more episodes per hour of apnoea, hypopnoea or arousal due to respiratory effort. The reproducibility of non-dipping status was confirmed through a second 24-h ABP monitoring performed at baseline. On top of the previous stable treatment regimen (which excluded calcium-channel blockers), a 10 mg dosing of barnidipine hydrochloride at bedtime was added to all subjects during a 12-week period[2].